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TargetDual specificity mitogen-activated protein kinase kinase 2
LigandBDBM50301961
Substrate/Competitorn/a
Meas. Tech.ChEMBL_598693 (CHEMBL1050774)
Ki 13000±n/a nM
Citation Wood, MRSchirripa, KMKim, JJQuigley, AGStump, CABell, IMBednar, RAFay, JFBruno, JGMoore, ELMosser, SDRoller, SSalvatore, CAKane, SAVacca, JPSelnick, HG Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility. Bioorg Med Chem Lett19:5787-90 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity mitogen-activated protein kinase kinase 2
Name:Dual specificity mitogen-activated protein kinase kinase 2
Synonyms:Dual specificity mitogen-activated protein kinase kinase 2 (MEK2) | Dual specificity mitogen-activated protein kinase kinase; MEK1/2 | ERK activator kinase 2 | MAP kinase kinase 2 | MAP2K2 | MAPK/ERK kinase 2 | MAPKK 2 | MEK2 | MKK2 | MP2K2_HUMAN | PRKMK2 | VHL-MAP2K1/MAP2K2
Type:Enzyme Catalytic Domain
Mol. Mass.:44423.61
Organism:Homo sapiens (Human)
Description:gi_13489054
Residue:400
Sequence:
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
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  Blast E-value cutoff:
BDBM50301961
n/a
NameBDBM50301961
Synonyms:(+/-)-N-(3-cyanobenzyl)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-ylamino)-2-oxoethyl)pivalamide | CHEMBL572225
TypeSmall organic molecule
Emp. Form.C27H29N5O4
Mol. Mass.487.5503
SMILESCN1C(=O)NC(=O)C11Cc2ccc(NC(=O)CN(Cc3cccc(c3)C#N)C(=O)C(C)(C)C)cc2C1
Structure
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