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TargetCalcitonin gene-related peptide type 1 receptor
LigandBDBM50301969
Substrate/Competitorn/a
Meas. Tech.ChEMBL_598692 (CHEMBL1050773)
Ki 0.13±n/a nM
Citation Wood, MRSchirripa, KMKim, JJQuigley, AGStump, CABell, IMBednar, RAFay, JFBruno, JGMoore, ELMosser, SDRoller, SSalvatore, CAKane, SAVacca, JPSelnick, HG Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility. Bioorg Med Chem Lett19:5787-90 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Calcitonin gene-related peptide type 1 receptor
Name:Calcitonin gene-related peptide type 1 receptor
Synonyms:Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:52980.45
Organism:Homo sapiens (Human)
Description:Q16602
Residue:461
Sequence:
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50301969
n/a
NameBDBM50301969
Synonyms:2a-(aminomethyl)-1-(((S)-2'-oxo-1',2',6,8-tetrahydrospiro[cyclopenta[g]quinoline-7,3'-pyrrolo[2,3-b]pyridine]-2-yl)methyl)-2a,3-dihydropyrrolo[4,3,2-de]quinoline-2,4(1H,5H)-dione | CHEMBL570933
TypeSmall organic molecule
Emp. Form.C30H24N6O3
Mol. Mass.516.55
SMILESNCC12CC(=O)Nc3cccc(N(Cc4ccc5cc6C[C@@]7(Cc6cc5n4)C(=O)Nc4ncccc74)C1=O)c23 |r|
Structure
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