| Reaction Details |
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 | Report a problem with these data |
| Target | Urotensin-2 receptor |
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| Ligand | BDBM50302248 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_596665 (CHEMBL1048827) |
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| IC50 | 16±n/a nM |
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| Citation |  Lawson, EC; Luci, DK; Ghosh, S; Kinney, WA; Reynolds, CH; Qi, J; Smith, CE; Wang, Y; Minor, LK; Haertlein, BJ; Parry, TJ; Damiano, BP; Maryanoff, BE Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits. J Med Chem52:7432-45 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urotensin-2 receptor |
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| Name: | Urotensin-2 receptor |
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| Synonyms: | G-protein coupled receptor 14 | G-protein coupled sensory epithelial neuropeptide-like receptor | Gpr14 | Senr | UR-II-R | UR2R_RAT | Urotensin-II | Uts2r |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42725.34 |
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| Organism: | RAT |
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| Description: | Urotensin-II UTS2R RAT::P49684 |
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| Residue: | 386 |
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| Sequence: | MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSA
MGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGD
VGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLL
TLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWL
SQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNY
LTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSG
RSLSSSSQQATETLMLSPVPRNGALL
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| BDBM50302248 |
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| n/a |
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| Name | BDBM50302248 |
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| Synonyms: | (R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-methylpiperazin-1-yl)-1,3-dioxoisoindolin-2-yl)butyl)thiophene-2-sulfonamide | CHEMBL567949 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H34N4O6S2 |
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| Mol. Mass. | 598.733 |
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| SMILES | COc1ccc(cc1OC)[C@@H](CCCNS(=O)(=O)c1cccs1)N1C(=O)c2cccc(N3CCN(C)CC3)c2C1=O |r| |
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| Structure | 
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