Reaction Details |
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Target | Urotensin-2 receptor |
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Ligand | BDBM50302271 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_596665 (CHEMBL1048827) |
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IC50 | 4±n/a nM |
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Citation | Lawson, EC; Luci, DK; Ghosh, S; Kinney, WA; Reynolds, CH; Qi, J; Smith, CE; Wang, Y; Minor, LK; Haertlein, BJ; Parry, TJ; Damiano, BP; Maryanoff, BE Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits. J Med Chem52:7432-45 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Urotensin-2 receptor |
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Name: | Urotensin-2 receptor |
Synonyms: | G-protein coupled receptor 14 | G-protein coupled sensory epithelial neuropeptide-like receptor | Gpr14 | Senr | UR-II-R | UR2R_RAT | Urotensin-II | Uts2r |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 42725.34 |
Organism: | RAT |
Description: | Urotensin-II UTS2R RAT::P49684 |
Residue: | 386 |
Sequence: | MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSA
MGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGD
VGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLL
TLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWL
SQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNY
LTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSG
RSLSSSSQQATETLMLSPVPRNGALL
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BDBM50302271 |
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n/a |
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Name | BDBM50302271 |
Synonyms: | (R)-2-(1-(3,4-dimethoxyphenyl)-4-(6-methoxypyrazin-2-ylamino)butyl)-4-(4-ethylpiperazin-1-yl)isoindolin-1-one | CHEMBL571625 |
Type | Small organic molecule |
Emp. Form. | C31H40N6O4 |
Mol. Mass. | 560.6871 |
SMILES | CCN1CCN(CC1)c1cccc2C(=O)N(Cc12)[C@H](CCCNc1cncc(OC)n1)c1ccc(OC)c(OC)c1 |r| |
Structure |
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