| Reaction Details |
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 | Report a problem with these data |
| Target | Urotensin-2 receptor |
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| Ligand | BDBM50302231 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_596666 (CHEMBL1048828) |
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| Ki | 230±n/a nM |
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| Citation |  Lawson, EC; Luci, DK; Ghosh, S; Kinney, WA; Reynolds, CH; Qi, J; Smith, CE; Wang, Y; Minor, LK; Haertlein, BJ; Parry, TJ; Damiano, BP; Maryanoff, BE Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits. J Med Chem52:7432-45 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urotensin-2 receptor |
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| Name: | Urotensin-2 receptor |
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| Synonyms: | G-protein coupled receptor 14 | GPR14 | UR-II-R | UR2R_HUMAN | UTS2R | Urotensin II receptor | Urotensin-II |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42159.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Urotensin-II UTS2R HUMAN::Q9UKP6 |
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| Residue: | 389 |
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| Sequence: | MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSA
MGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGD
VGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLL
TLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRR
SQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLT
TCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLS
SCSPQPTDSLVLAPAAPARPAPEGPRAPA
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| BDBM50302231 |
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| n/a |
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| Name | BDBM50302231 |
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| Synonyms: | 2-((R)-1-(3,4-dimethoxyphenyl)ethyl)-4-(4-((R)-1-phenylethyl)piperazin-1-yl)isoindoline-1,3-dione | CHEMBL571683 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33N3O4 |
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| Mol. Mass. | 499.6007 |
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| SMILES | COc1ccc(cc1OC)[C@@H](C)N1C(=O)c2cccc(N3CCN(CC3)[C@H](C)c3ccccc3)c2C1=O |r| |
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| Structure | 
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