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TargetProstaglandin E synthase
LigandBDBM50271108
Substrate/Competitorn/a
Meas. Tech.ChEMBL_597590 (CHEMBL1050553)
IC50 1±n/a nM
Citation Giroux, ABoulet, LBrideau, CChau, AClaveau, DCôté, BEthier, DFrenette, RGagnon, MGuay, JGuiral, SMancini, JMartins, EMassé, FMéthot, NRiendeau, DRubin, JXu, DYu, HDucharme, YFriesen, RW Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett19:5837-41 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E synthase
Name:Prostaglandin E synthase
Synonyms:MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:Protein
Mol. Mass.:17112.22
Organism:Homo sapiens (Human)
Description:n/a
Residue:152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50271108
n/a
NameBDBM50271108
Synonyms:2-(6-chloro-9-(3-hydroxy-3-methylbut-1-ynyl)-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile | CHEMBL483900
TypeSmall organic molecule
Emp. Form.C28H17ClN4O
Mol. Mass.460.914
SMILESCC(C)(O)C#Cc1ccc2c3[nH]c(nc3c3ccc(Cl)cc3c2c1)-c1c(cccc1C#N)C#N
Structure
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