| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C theta type |
|---|
| Ligand | BDBM50302511 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_597635 (CHEMBL1039087) |
|---|
| IC50 | 13±n/a nM |
|---|
| Citation |  Niu, C; Boschelli, DH; Tumey, LN; Bhagirath, N; Subrath, J; Shim, J; Wang, Y; Wu, B; Eid, C; Lee, J; Yang, X; Brennan, A; Chaudhary, D First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. Bioorg Med Chem Lett19:5829-32 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C theta type |
|---|
| Name: | Protein kinase C theta type |
|---|
| Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 81878.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Full-length human PKC theta (Panvera Catalog No. P2996). |
|---|
| Residue: | 706 |
|---|
| Sequence: | MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
|
|
|
|---|
| BDBM50302511 |
|---|
| n/a |
|---|
| Name | BDBM50302511 |
|---|
| Synonyms: | 4-(3H-indol-4-ylamino)-5-styrylnicotinonitrile | CHEMBL576232 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H16N4 |
|---|
| Mol. Mass. | 336.3892 |
|---|
| SMILES | N#Cc1cncc(C=Cc2ccccc2)c1Nc1cccc2[nH]ccc12 |w:7.6| |
|---|
| Structure | 
|
|---|
Search and Browse
