| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C theta type |
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| Ligand | BDBM50302513 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_597635 (CHEMBL1039087) |
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| IC50 | 4700±n/a nM |
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| Citation |  Niu, C; Boschelli, DH; Tumey, LN; Bhagirath, N; Subrath, J; Shim, J; Wang, Y; Wu, B; Eid, C; Lee, J; Yang, X; Brennan, A; Chaudhary, D First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. Bioorg Med Chem Lett19:5829-32 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C theta type |
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| Name: | Protein kinase C theta type |
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| Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 81878.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length human PKC theta (Panvera Catalog No. P2996). |
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| Residue: | 706 |
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| Sequence: | MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
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| BDBM50302513 |
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| n/a |
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| Name | BDBM50302513 |
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| Synonyms: | 4-(1-methyl-1H-indol-5-ylamino)-5-styrylnicotinonitrile | CHEMBL568186 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18N4 |
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| Mol. Mass. | 350.4158 |
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| SMILES | Cn1ccc2cc(Nc3c(\C=C\c4ccccc4)cncc3C#N)ccc12 |
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| Structure | 
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