Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50302775 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_595271 (CHEMBL1043623) |
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EC50 | 141±n/a nM |
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Citation | Jones, P; Griffin, AM; Gawell, L; Lavoie, R; Delorme, D; Roberts, E; Brown, W; Walpole, C; Xiao, W; Boulet, J; Labarre, M; Coupal, M; Butterworth, J; St-Onge, S; Hodzic, L; Salois, D N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: the development of diaryl amino piperidines as potent delta opioid receptor agonists with in vivo anti-nociceptive activity in rodent models. Bioorg Med Chem Lett19:5994-8 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50302775 |
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n/a |
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Name | BDBM50302775 |
Synonyms: | CHEMBL569084 | N,N-diethyl-4-((3-methoxyphenyl)(1-phenethylpiperidin-4-yl)amino)benzamide |
Type | Small organic molecule |
Emp. Form. | C31H39N3O2 |
Mol. Mass. | 485.6603 |
SMILES | CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(CCc2ccccc2)CC1)c1cccc(OC)c1 |
Structure |
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