| Reaction Details |
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 | Report a problem with these data |
| Target | Calcitonin gene-related peptide type 1 receptor |
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| Ligand | BDBM50302875 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_595485 (CHEMBL1046104) |
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| Ki | 6.6±n/a nM |
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| Citation |  Burgey, CS; Potteiger, CM; Deng, JZ; Mosser, SD; Salvatore, CA; Yu, S; Roller, S; Kane, SA; Vacca, JP; Williams, TM Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines. Bioorg Med Chem Lett19:6368-72 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcitonin gene-related peptide type 1 receptor |
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| Name: | Calcitonin gene-related peptide type 1 receptor |
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| Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52980.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16602 |
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| Residue: | 461 |
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| Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
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| BDBM50302875 |
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| n/a |
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| Name | BDBM50302875 |
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| Synonyms: | CHEMBL570748 | N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl)-4-(6-methyl-3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28F5N5O3 |
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| Mol. Mass. | 541.5135 |
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| SMILES | Cc1cc(C2CCN(CC2)C(=O)N[C@@H]2CC[C@H](CN(CC(F)(F)F)C2=O)c2cccc(F)c2F)c(=O)[nH]n1 |r| |
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| Structure | 
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