Ki Summary

Reaction Details

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Target

Dual specificity protein kinase CLK3

Ligand

BDBM80396

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_596747 (CHEMBL1039035)

3000±n/a nM

Citation

Mott, BT; Tanega, C; Shen, M; Maloney, DJ; Shinn, P; Leister, W; Marugan, JJ; Inglese, J; Austin, CP; Misteli, T; Auld, DS; Thomas, CJ Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). Bioorg Med Chem Lett19:6700-5 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Dual specificity protein kinase CLK3

Name:

Dual specificity protein kinase CLK3

Synonyms:

CDC2-like kinase 3 (CLK3) | CLK3 | CLK3_HUMAN | Dual specificity protein kinase CLK3

Type:

Protein

Mol. Mass.:

73570.11

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

638

Sequence:

MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGG
GPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGL
PRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEG
RLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHR
RRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWL
QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKD
KENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALR
FLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHT
TIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP
IPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRM
LEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR

BDBM80396

n/a

Name

BDBM80396

Synonyms:

(1E)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)-2-propanone | (1E)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)acetone | (1E)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one | CHEMBL408982 | MLS000518915 | SMR000129335 | cid_1893667

Type

Small organic molecule

Emp. Form.

C13H15NO2S

Mol. Mass.

249.329

SMILES

CCN1C(Sc2ccc(OC)cc12)=CC(C)=O |w:13.15|

Structure