Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase B-raf

Ligand

BDBM50303112

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_597720 (CHEMBL1043507)

IC50

4.90±n/a nM

Citation

Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Novel pyrazolopyrimidines as highly potent B-Raf inhibitors. Bioorg Med Chem Lett19:6957-61 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase B-raf

Name:

Serine/threonine-protein kinase B-raf

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

84446.00

Organism:

Homo sapiens (Human)

Description:

P15056

Residue:

766

Sequence:

MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH

BDBM50303112

n/a

Name

BDBM50303112

Synonyms:

3-(1H-indazol-4-yl)-7-(8-(methylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine | CHEMBL570453

Type

Small organic molecule

Emp. Form.

C26H25N7O2S

Mol. Mass.

499.587

SMILES

CS(=O)(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 |THB:12:10:4:6.7,(-3.77,1.28,;-5.1,.49,;-6.44,-.27,;-6.43,1.27,;-5.06,-1.05,;-5.6,-2.52,;-7.12,-3.2,;-5.75,-3.16,;-4.56,-2.3,;-3.02,-3.14,;-3.56,-4.62,;-4,-3.43,;-3.56,-6.16,;-4.88,-6.93,;-4.89,-8.47,;-3.55,-9.24,;-2.22,-8.47,;-.75,-8.94,;.16,-7.69,;-.75,-6.44,;-2.22,-6.92,;1.7,-7.69,;2.47,-9.03,;4,-9.03,;4.77,-7.69,;4,-6.35,;2.46,-6.36,;-.68,-10.48,;-1.98,-11.3,;-1.92,-12.84,;-.56,-13.56,;.75,-12.74,;2.25,-13.15,;3.1,-11.86,;2.13,-10.65,;.68,-11.19,)|

Structure