Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase B-raf

Ligand

BDBM50303117

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_597720 (CHEMBL1043507)

IC50

39.4±n/a nM

Citation

Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Novel pyrazolopyrimidines as highly potent B-Raf inhibitors. Bioorg Med Chem Lett19:6957-61 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase B-raf

Name:

Serine/threonine-protein kinase B-raf

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

84446.00

Organism:

Homo sapiens (Human)

Description:

P15056

Residue:

766

Sequence:

MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH

BDBM50303117

n/a

Name

BDBM50303117

Synonyms:

(2R)-tert-butyl 1-(3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carbonyl)pyrrolidine-2-carboxylate | CHEMBL571747

Type

Small organic molecule

Emp. Form.

C35H38N8O3

Mol. Mass.

618.728

SMILES

CC(C)(C)OC(=O)[C@H]1CCCN1C(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 |r,wU:7.6,THB:22:20:14:16.17,(10.21,-19.41,;10,-20.93,;8.57,-21.52,;8.74,-20.04,;11.22,-21.88,;11.15,-23.42,;9.79,-24.13,;12.45,-24.24,;13.91,-23.75,;14.83,-24.99,;13.93,-26.25,;12.47,-25.79,;11.23,-26.71,;9.88,-25.96,;11.26,-28.24,;10.72,-29.71,;9.2,-30.39,;10.57,-30.36,;11.76,-29.49,;13.3,-30.34,;12.76,-31.81,;12.32,-30.62,;12.77,-33.35,;11.44,-34.12,;11.43,-35.67,;12.77,-36.44,;14.1,-35.67,;15.58,-36.14,;16.49,-34.89,;15.58,-33.64,;14.1,-34.12,;18.02,-34.89,;18.79,-36.22,;20.33,-36.22,;21.1,-34.89,;20.32,-33.55,;18.79,-33.56,;15.64,-37.68,;14.34,-38.5,;14.4,-40.05,;15.77,-40.76,;17.07,-39.94,;18.57,-40.35,;19.42,-39.06,;18.46,-37.85,;17.01,-38.39,)|

Structure