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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase B-raf | ||
| Ligand | BDBM50303119 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_597720 (CHEMBL1043507) | ||
| IC50 | 67±n/a nM | ||
| Citation |  Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Novel pyrazolopyrimidines as highly potent B-Raf inhibitors. Bioorg Med Chem Lett19:6957-61 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase B-raf | |||
| Name: | Serine/threonine-protein kinase B-raf | ||
| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 84446.00 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P15056 | ||
| Residue: | 766 | ||
| Sequence: |
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| BDBM50303119 | |||
| n/a | |||
| Name | BDBM50303119 | ||
| Synonyms: | 3-(1H-indazol-4-yl)-7-(8-isopropyl-8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine | CHEMBL570648 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H29N7 | ||
| Mol. Mass. | 463.5768 | ||
| SMILES | CC(C)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 |THB:11:9:3:5.6,(-4.36,3.26,;-5.68,2.47,;-7.03,3.22,;-5.65,.93,;-6.19,-.53,;-7.71,-1.21,;-6.34,-1.18,;-5.15,-.32,;-3.61,-1.16,;-4.15,-2.63,;-4.59,-1.45,;-4.15,-4.17,;-5.47,-4.94,;-5.48,-6.49,;-4.14,-7.26,;-2.81,-6.49,;-1.34,-6.96,;-.43,-5.71,;-1.34,-4.46,;-2.81,-4.94,;1.11,-5.71,;1.88,-7.04,;3.41,-7.04,;4.18,-5.71,;3.41,-4.37,;1.87,-4.38,;-1.27,-8.5,;-2.57,-9.32,;-2.51,-10.86,;-1.15,-11.58,;.16,-10.76,;1.66,-11.17,;2.51,-9.88,;1.54,-8.66,;.09,-9.21,)| | ||
| Structure | 
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