Reaction Details | |||
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Target | Serine/threonine-protein kinase B-raf | ||
Ligand | BDBM50303124 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_597720 (CHEMBL1043507) | ||
IC50 | 3.8±n/a nM | ||
Citation | Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Novel pyrazolopyrimidines as highly potent B-Raf inhibitors. Bioorg Med Chem Lett19:6957-61 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase B-raf | |||
Name: | Serine/threonine-protein kinase B-raf | ||
Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 84446.00 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P15056 | ||
Residue: | 766 | ||
Sequence: |
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BDBM50303124 | |||
n/a | |||
Name | BDBM50303124 | ||
Synonyms: | 7-(8-azabicyclo[3.2.1]octan-3-yl)-3-(7-fluoro-1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine | CHEMBL584527 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H22FN7 | ||
Mol. Mass. | 439.4875 | ||
SMILES | Fc1ccc(-c2c(nn3c(ccnc23)C2CC3CCC(C2)N3)-c2ccncc2)c2cn[nH]c12 |TLB:9:14:21:17.18,(31.91,-31.64,;31.85,-30.1,;30.48,-29.38,;30.43,-27.84,;31.72,-27.02,;31.66,-25.48,;32.57,-24.24,;31.66,-22.98,;30.18,-23.46,;28.85,-22.7,;27.52,-23.47,;27.52,-25.01,;28.85,-25.78,;30.18,-25.01,;28.84,-21.16,;28.4,-19.97,;26.81,-19.06,;25.29,-19.74,;26.66,-19.7,;27.85,-18.84,;29.39,-19.69,;27.34,-17.59,;34.1,-24.23,;34.87,-25.57,;36.41,-25.57,;37.18,-24.23,;36.4,-22.9,;34.86,-22.9,;33.09,-27.73,;34.54,-27.19,;35.5,-28.4,;34.65,-29.69,;33.16,-29.28,)| | ||
Structure |