| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein phosphatase 1 |
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| Ligand | BDBM28884 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_595101 (CHEMBL1047961) |
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| IC50 | 2800±n/a nM |
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| Citation |  Wu, S; Vossius, S; Rahmouni, S; Miletic, AV; Vang, T; Vazquez-Rodriguez, J; Cerignoli, F; Arimura, Y; Williams, S; Hayes, T; Moutschen, M; Vasile, S; Pellecchia, M; Mustelin, T; Tautz, L Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J Med Chem52:6716-23 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein phosphatase 1 |
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| Name: | Dual specificity protein phosphatase 1 |
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| Synonyms: | CL100 | DUS1_HUMAN | DUSP1 | Dual specificity protein phosphatase hVH1 | MAP kinase phosphatase 1 | MKP-1 | MKP1 | PTPN10 | Protein-tyrosine phosphatase CL100 | VH1 |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 39301.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_4758204 |
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| Residue: | 367 |
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| Sequence: | MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAM
GLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFF
LKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPF
LYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEA
IDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFS
FMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSP
ITTSPSC
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| BDBM28884 |
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| n/a |
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| Name | BDBM28884 |
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| Synonyms: | 2-[(5Z)-4-oxo-5-({1-phenyl-3-[4-(piperidine-1-sulfonyl)phenyl]-1H-pyrazol-4-yl}methylidene)-2-sulfanylidene-1,3-thiazolidin-3-yl]ethane-1-sulfonic acid | rhodanine derivative, 43 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26N4O6S4 |
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| Mol. Mass. | 618.768 |
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| SMILES | OS(=O)(=O)CCN1C(=S)S\C(=C/c2cn(nc2-c2ccc(cc2)S(=O)(=O)N2CCCCC2)-c2ccccc2)C1=O |
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| Structure | 
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