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TargetNeutrophil elastase
LigandBDBM50303360
Substrate/Competitorn/a
Meas. Tech.ChEMBL_595760 (CHEMBL1045283)
Ki 219±n/a nM
Citation Mulchande, JOliveira, RCarrasco, MGouveia, LGuedes, RCIley, JMoreira, R 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem53:241-53 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50303360
n/a
NameBDBM50303360
Synonyms:CHEMBL271820 | ethyl 2-(3,3-Diethyl-2,4-dioxoazetidin-1-yl)acetate
TypeSmall organic molecule
Emp. Form.C11H17NO4
Mol. Mass.227.257
SMILESCCOC(=O)CN1C(=O)C(CC)(CC)C1=O
Structure
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