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TargetKallikrein-4
LigandBDBM50303436
Substrate/Competitorn/a
Meas. Tech.ChEMBL_595923 (CHEMBL1041781)
IC50 9772.37±n/a nM
Citation Mott, BTFerreira, RSSimeonov, AJadhav, AAng, KKLeister, WShen, MSilveira, JTDoyle, PSArkin, MRMcKerrow, JHInglese, JAustin, CPThomas, CJShoichet, BKMaloney, DJ Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem53:52-60 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kallikrein-4
Name:Kallikrein-4
Synonyms:EMSP1 | Enamel matrix serine proteinase 1 | KLK-L1 | KLK4 | KLK4_HUMAN | Kallikrein 4 | Kallikrein-4 | Kallikrein-like protein 1 | PRSS17 | PSTS | Prostase | Serine protease 17
Type:PROTEIN
Mol. Mass.:27022.83
Organism:Homo sapiens (Human)
Description:ChEMBL_595923
Residue:254
Sequence:
MATAGNPWGWFLGYLILGVAGSLVSGSCSQIINGEDCSPHSQPWQAALVMENELFCSGVL
VHPQWVLSAAHCFQNSYTIGLGLHSLEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLI
KLDESVSESDTIRSISIASQCPTAGNSCLVSGWGLLANGRMPTVLQCVNVSVVSEEVCSK
LYDPLYHPSMFCAGGGHDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNL
CKFTEWIEKTVQAS
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  Blast E-value cutoff:
BDBM50303436
n/a
NameBDBM50303436
Synonyms:9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-9H-purine-2-carbonitrile | CHEMBL578159
TypeSmall organic molecule
Emp. Form.C14H8F4N6
Mol. Mass.336.2471
SMILESFC(F)Cn1cnc2c(Nc3cc(F)cc(F)c3)nc(nc12)C#N
Structure
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