| Reaction Details |
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 | Report a problem with these data |
| Target | Papain |
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| Ligand | BDBM50303417 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_595888 (CHEMBL1040868) |
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| IC50 | 389.05±n/a nM |
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| Citation |  Mott, BT; Ferreira, RS; Simeonov, A; Jadhav, A; Ang, KK; Leister, W; Shen, M; Silveira, JT; Doyle, PS; Arkin, MR; McKerrow, JH; Inglese, J; Austin, CP; Thomas, CJ; Shoichet, BK; Maloney, DJ Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem53:52-60 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Papain |
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| Name: | Papain |
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| Synonyms: | Allergen=Car p 1 | PAPA1_CARPA | PPI | Papaya proteinase I |
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| Type: | Enzyme |
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| Mol. Mass.: | 38923.01 |
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| Organism: | Carica papaya |
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| Description: | Papain was purchased from Sigma, Germany. |
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| Residue: | 345 |
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| Sequence: | MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYK
NIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTE
LSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNE
YSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKT
DGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYG
PNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
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| BDBM50303417 |
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| n/a |
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| Name | BDBM50303417 |
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| Synonyms: | 4-(Cyclopentylamino)-6-(3,5-difluorophenylamino)-1,3,5-triazine-2-carbonitrile | CHEMBL568171 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14F2N6 |
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| Mol. Mass. | 316.3087 |
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| SMILES | Fc1cc(F)cc(Nc2nc(NC3CCCC3)nc(n2)C#N)c1 |
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| Structure | 
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