Reaction Details |
| Report a problem with these data |
Target | Cathepsin Z |
---|
Ligand | BDBM50303410 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_595889 (CHEMBL1040869) |
---|
IC50 | 6456.54±n/a nM |
---|
Citation | Mott, BT; Ferreira, RS; Simeonov, A; Jadhav, A; Ang, KK; Leister, W; Shen, M; Silveira, JT; Doyle, PS; Arkin, MR; McKerrow, JH; Inglese, J; Austin, CP; Thomas, CJ; Shoichet, BK; Maloney, DJ Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem53:52-60 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cathepsin Z |
---|
Name: | Cathepsin Z |
Synonyms: | CATZ_HUMAN | CTSZ | Cathepsin P | Cathepsin X |
Type: | PROTEIN |
Mol. Mass.: | 33870.59 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_595889 |
Residue: | 303 |
Sequence: | MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPA
DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSV
QNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECH
AIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYIN
HVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGD
PIV
|
|
|
BDBM50303410 |
---|
n/a |
---|
Name | BDBM50303410 |
Synonyms: | 4-(3-chlorophenylamino)-6-(cyclopentylamino)-1,3,5-triazine-2-carbonitrile | CHEMBL567785 |
Type | Small organic molecule |
Emp. Form. | C15H15ClN6 |
Mol. Mass. | 314.773 |
SMILES | Clc1cccc(Nc2nc(NC3CCCC3)nc(n2)C#N)c1 |
Structure |
|