Reaction Details |
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Target | Cathepsin Z |
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Ligand | BDBM50303420 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_595889 (CHEMBL1040869) |
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IC50 | 933.25±n/a nM |
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Citation | Mott, BT; Ferreira, RS; Simeonov, A; Jadhav, A; Ang, KK; Leister, W; Shen, M; Silveira, JT; Doyle, PS; Arkin, MR; McKerrow, JH; Inglese, J; Austin, CP; Thomas, CJ; Shoichet, BK; Maloney, DJ Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem53:52-60 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin Z |
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Name: | Cathepsin Z |
Synonyms: | CATZ_HUMAN | CTSZ | Cathepsin P | Cathepsin X |
Type: | PROTEIN |
Mol. Mass.: | 33870.59 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_595889 |
Residue: | 303 |
Sequence: | MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPA
DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSV
QNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECH
AIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYIN
HVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGD
PIV
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BDBM50303420 |
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n/a |
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Name | BDBM50303420 |
Synonyms: | 6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-carbonitrile | 6-[(3,5-difluorophenyl)amino]-9-ethyl-9H-purine-2-carbonitrile | CHEMBL567341 |
Type | Small organic molecule |
Emp. Form. | C14H10F2N6 |
Mol. Mass. | 300.2662 |
SMILES | CCn1cnc2c(Nc3cc(F)cc(F)c3)nc(nc12)C#N |
Structure |
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