| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 9 |
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| Ligand | BDBM50303591 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_596267 (CHEMBL1050683) |
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| IC50 | 100±n/a nM |
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| Citation |  Klüter, S; Grütter, C; Naqvi, T; Rabiller, M; Simard, JR; Pawar, V; Getlik, M; Rauh, D Displacement assay for the detection of stabilizers of inactive kinase conformations. J Med Chem53:357-67 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 9 |
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| Name: | Mitogen-activated protein kinase 9 |
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| Synonyms: | JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48131.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
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| Residue: | 424 |
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| Sequence: | MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL
EGCR
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| BDBM50303591 |
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| n/a |
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| Name | BDBM50303591 |
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| Synonyms: | 1-(4-(6-aminoquinolin-4-ylamino)phenyl)-3-(3-tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)urea | 1-{4-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea | CHEMBL570904 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31N7O |
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| Mol. Mass. | 505.6134 |
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| SMILES | Cc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(Nc2ccnc3ccc(N)cc23)cc1)C(C)(C)C |
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| Structure | 
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