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TargetProstaglandin E2 receptor
LigandBDBM50254473
Substrate/Competitorn/a
Meas. Tech.ChEMBL_596834
IC50 5±n/a nM
Citation Singh JZeller WZhou NHategan GMishra RKPolozov AYu POnua EZhang JRamírez JLSigthorsson GThorsteinnsdottir MKiselyov ASZembower DEAndrésson TGurney ME Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that J Med Chem 53:18-36 (2010) [PubMed]  Article
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Prostaglandin E2 receptor
Name:Prostaglandin E2 receptor
Synonyms:PGE receptor, EP3 subtype | PGE2-R | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:Enzyme
Mol. Mass.:43335.03
Organism:Homo sapiens (Human)
Description:P43115
Residue:390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI
RYHTNNYASSSTSLPCQCSSTLMWSDHLER
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BDBM50254473
n/a
NameBDBM50254473
Synonyms:4,5-Dichlorothiophene-2-sulfonic Acid[2-(3-Naphthalen-2-ylmethyl-1H-indol-4-yloxy)acetyl]amide | CHEMBL467632 | N-(4,5-dichlorothiophen-2-ylsulfonyl)-2-(3-(naphthalen-2-ylmethyl)-1H-indol-4-yloxy)acetamide
TypeSmall organic molecule
Emp. Form.C25H18Cl2N2O4S2
Mol. Mass.545.457
SMILESClc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Cc3ccc4ccccc4c3)c12
Structure
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