| Reaction Details |
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 | Report a problem with these data |
| Target | Proprotein convertase subtilisin/kexin type 6 |
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| Ligand | BDBM50303774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_597564 (CHEMBL1049701) |
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| Ki | 0.600000±n/a nM |
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| Citation |  Becker, GL; Sielaff, F; Than, ME; Lindberg, I; Routhier, S; Day, R; Lu, Y; Garten, W; Steinmetzer, T Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem53:1067-75 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proprotein convertase subtilisin/kexin type 6 |
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| Name: | Proprotein convertase subtilisin/kexin type 6 |
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| Synonyms: | PACE4 | PCSK6 | PCSK6_HUMAN | Subtilisin/kexin type 6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 106442.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1290742 |
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| Residue: | 969 |
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| Sequence: | MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL
GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC
VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS
ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR
CDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQF
CCRTCLLAG
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| BDBM50303774 |
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| n/a |
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| Name | BDBM50303774 |
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| Synonyms: | CHEMBL566340 | phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide |
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| Type | Small organic molecule |
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| Emp. Form. | C33H50N12O4 |
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| Mol. Mass. | 678.8281 |
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| SMILES | [#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-c1ccc(cc1)-[#6](-[#7])=[#7] |r| |
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| Structure | 
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