| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuroendocrine convertase 1 |
|---|
| Ligand | BDBM50303778 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_597567 (CHEMBL1049704) |
|---|
| Ki | 70±n/a nM |
|---|
| Citation |  Becker, GL; Sielaff, F; Than, ME; Lindberg, I; Routhier, S; Day, R; Lu, Y; Garten, W; Steinmetzer, T Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem53:1067-75 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuroendocrine convertase 1 |
|---|
| Name: | Neuroendocrine convertase 1 |
|---|
| Synonyms: | NEC1 | NEC1_HUMAN | PCSK1 | Prohormone convertase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 84143.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_597567 |
|---|
| Residue: | 753 |
|---|
| Sequence: | MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQ
IGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNL
FNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYAN
YDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRM
LDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKG
SIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDY
TDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPL
ANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALK
ANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERE
RDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEH
MKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEE
GAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSL
YNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN
|
|
|
|---|
| BDBM50303778 |
|---|
| n/a |
|---|
| Name | BDBM50303778 |
|---|
| Synonyms: | (S)-N-((1-carbamimidoylpiperidin-4-yl)methyl)-5-guanidino-2-((S)-2-((S)-5-guanidino-2-(2-phenylacetamido)pentanamido)-3-methylbutanamido)pentanamide | CHEMBL568067 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H55N13O4 |
|---|
| Mol. Mass. | 685.8638 |
|---|
| SMILES | [#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](-[#7])=[#7] |r| |
|---|
| Structure | 
|
|---|
Search and Browse
