| Reaction Details |
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 | Report a problem with these data |
| Target | Furin |
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| Ligand | BDBM50303778 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_597562 (CHEMBL1049699) |
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| Ki | 53±n/a nM |
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| Citation |  Becker, GL; Sielaff, F; Than, ME; Lindberg, I; Routhier, S; Day, R; Lu, Y; Garten, W; Steinmetzer, T Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem53:1067-75 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Furin |
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| Name: | Furin |
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| Synonyms: | FUR | FURIN | FURIN_HUMAN | Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA | PACE | PCSK3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 86676.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09958 |
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| Residue: | 794 |
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| Sequence: | MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI
FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ
QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV
SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH
ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL
SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL
SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG
RGERTAFIKDQSAL
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| BDBM50303778 |
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| n/a |
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| Name | BDBM50303778 |
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| Synonyms: | (S)-N-((1-carbamimidoylpiperidin-4-yl)methyl)-5-guanidino-2-((S)-2-((S)-5-guanidino-2-(2-phenylacetamido)pentanamido)-3-methylbutanamido)pentanamide | CHEMBL568067 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H55N13O4 |
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| Mol. Mass. | 685.8638 |
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| SMILES | [#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](-[#7])=[#7] |r| |
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| Structure | 
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