| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxanthine-guanine phosphoribosyltransferase |
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| Ligand | BDBM50304141 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_602349 (CHEMBL1041579) |
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| Ki | 300±n/a nM |
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| Citation |  Hocková, D; Holý, A; Masojídková, M; Keough, DT; de Jersey, J; Guddat, LW Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorg Med Chem17:6218-32 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxanthine-guanine phosphoribosyltransferase |
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| Name: | Hypoxanthine-guanine phosphoribosyltransferase |
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| Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
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| Type: | Protein |
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| Mol. Mass.: | 24579.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00492 |
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| Residue: | 218 |
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| Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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| BDBM50304141 |
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| n/a |
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| Name | BDBM50304141 |
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| Synonyms: | 9-[2-(1-Phosphonobutan-2-yloxy)ethyl]guanine | CHEMBL610201 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H18N5O5P |
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| Mol. Mass. | 331.2649 |
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| SMILES | CCC(CP(O)(O)=O)OCCn1cnc2c1nc(N)[nH]c2=O |
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| Structure | 
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