| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 1 |
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| Ligand | BDBM50304266 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_605767 (CHEMBL1073263) |
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| IC50 | 400±n/a nM |
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| Citation |  Zhuang, W; Zhao, X; Zhao, G; Guo, L; Lian, Y; Zhou, J; Fang, D Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors. Bioorg Med Chem17:6540-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent GABA transporter 1 |
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| Name: | Sodium- and chloride-dependent GABA transporter 1 |
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| Synonyms: | GABA transporter | GABA transporter 1 | Gabt1 | Gat-1 | Gat1 | SC6A1_MOUSE | Slc6a1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67006.26 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_788602 |
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| Residue: | 599 |
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| Sequence: | MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
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| BDBM50304266 |
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| n/a |
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| Name | BDBM50304266 |
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| Synonyms: | (S)-2-(1-(4,4-diphenylbut-3-enyl)pyrrolidin-2-yl)acetic acid | CHEMBL594213 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25NO2 |
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| Mol. Mass. | 335.4394 |
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| SMILES | [#8]-[#6](=O)-[#6]-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6]=[#6](\c1ccccc1)-c1ccccc1 |r| |
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| Structure | 
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