| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 1 |
|---|
| Ligand | BDBM50304267 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_605767 (CHEMBL1073263) |
|---|
| IC50 | 650±n/a nM |
|---|
| Citation |  Zhuang, W; Zhao, X; Zhao, G; Guo, L; Lian, Y; Zhou, J; Fang, D Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors. Bioorg Med Chem17:6540-6 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent GABA transporter 1 |
|---|
| Name: | Sodium- and chloride-dependent GABA transporter 1 |
|---|
| Synonyms: | GABA transporter | GABA transporter 1 | Gabt1 | Gat-1 | Gat1 | SC6A1_MOUSE | Slc6a1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 67006.26 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_788602 |
|---|
| Residue: | 599 |
|---|
| Sequence: | MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
|
|
|
|---|
| BDBM50304267 |
|---|
| n/a |
|---|
| Name | BDBM50304267 |
|---|
| Synonyms: | (S)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)pyrrolidine-2-carboxylic acid | CHEMBL604056 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23NO2S2 |
|---|
| Mol. Mass. | 361.521 |
|---|
| SMILES | [#6]-c1ccsc1\[#6](=[#6]/[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](-[#8])=O)-c1sccc1-[#6] |r| |
|---|
| Structure | 
|
|---|
Search and Browse
