| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hepatocyte nuclear factor 4-alpha |
|---|
| Ligand | BDBM50304341 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_606516 (CHEMBL1065467) |
|---|
| EC50 | 2570±n/a nM |
|---|
| Citation |  Le Guével, R; Oger, F; Lecorgne, A; Dudasova, Z; Chevance, S; Bondon, A; Barath, P; Simonneaux, G; Salbert, G Identification of small molecule regulators of the nuclear receptor HNF4alpha based on naphthofuran scaffolds. Bioorg Med Chem17:7021-30 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hepatocyte nuclear factor 4-alpha |
|---|
| Name: | Hepatocyte nuclear factor 4-alpha |
|---|
| Synonyms: | HNF4 | HNF4A | HNF4A_HUMAN | NR2A1 | TCF14 | hepatocyte nuclear factor 4-alpha isoform b |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52790.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_606516 |
|---|
| Residue: | 474 |
|---|
| Sequence: | MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC
FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK
IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK
DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK
GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL
FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW
PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
|
|
|
|---|
| BDBM50304341 |
|---|
| n/a |
|---|
| Name | BDBM50304341 |
|---|
| Synonyms: | 7-Methoxy-2-nitro-naphtho[2,1-b]furan | 7-methoxy-2-nitronaphtho[2,1-b]furan | CHEMBL7645 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H9NO4 |
|---|
| Mol. Mass. | 243.2149 |
|---|
| SMILES | COc1ccc2c3cc(oc3ccc2c1)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
