| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50304377 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_602874 (CHEMBL1038417) |
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| EC50 | 20±n/a nM |
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| Citation |  Takahashi, K; Hashimoto, N; Nakama, C; Kamata, K; Sasaki, K; Yoshimoto, R; Ohyama, S; Hosaka, H; Maruki, H; Nagata, Y; Eiki, J; Nishimura, T The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg Med Chem17:7042-51 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50304377 |
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| n/a |
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| Name | BDBM50304377 |
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| Synonyms: | 3-({5-[4-(Ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1Hbenzimidazol-6-yl}methyl)-1,3-oxazolidine-2,4-dione | CHEMBL596026 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20N4O6S |
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| Mol. Mass. | 492.504 |
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| SMILES | CCS(=O)(=O)c1ccc(Oc2cc3[nH]c(nc3cc2Cn2c(O)coc2=O)-c2ccccn2)cc1 |
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| Structure | 
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