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TargetHistamine H4 receptor
LigandBDBM50304504
Substrate/Competitorn/a
Meas. Tech.ChEMBL_603902 (CHEMBL1048581)
Ki 341±n/a nM
Citation Sander, KKottke, TTanrikulu, YProschak, EWeizel, LSchneider, EHSeifert, RSchneider, GStark, H 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem17:7186-96 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 receptor
Name:Histamine H4 receptor
Synonyms:AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44517.02
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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BDBM50304504
n/a
NameBDBM50304504
Synonyms:4-((2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)methyl)benzonitrile | CHEMBL609289
TypeSmall organic molecule
Emp. Form.C17H21N7
Mol. Mass.323.3955
SMILESCN1CCN(CC1)c1cc(NCc2ccc(cc2)C#N)nc(N)n1
Structure
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