Reaction Details |
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Target | Histamine H1 receptor |
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Ligand | BDBM50304524 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_604062 (CHEMBL1046851) |
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Ki | >1000±n/a nM |
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Citation | Sander, K; Kottke, T; Tanrikulu, Y; Proschak, E; Weizel, L; Schneider, EH; Seifert, R; Schneider, G; Stark, H 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem17:7186-96 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H1 receptor |
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Name: | Histamine H1 receptor |
Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 55808.72 |
Organism: | Homo sapiens (Human) |
Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
Residue: | 487 |
Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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BDBM50304524 |
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n/a |
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Name | BDBM50304524 |
Synonyms: | CHEMBL594721 | N4-(2-Chlorobenzyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine |
Type | Small organic molecule |
Emp. Form. | C16H21ClN6 |
Mol. Mass. | 332.831 |
SMILES | CN1CCN(CC1)c1cc(NCc2ccccc2Cl)nc(N)n1 |
Structure |
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