Reaction Details |
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Target | Vitamin D3 receptor |
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Ligand | BDBM50304583 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_606218 (CHEMBL1067951) |
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Ki | 0.1±n/a nM |
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Citation | Barycki, R; Sicinski, RR; Plum, LA; Grzywacz, P; Clagett-Dame, M; Deluca, HF Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity. Bioorg Med Chem17:7658-69 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Vitamin D3 receptor |
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Name: | Vitamin D3 receptor |
Synonyms: | Nr1i1 | VDR_RAT | Vdr | Vitamin D receptor |
Type: | PROTEIN |
Mol. Mass.: | 47811.07 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1505946 |
Residue: | 423 |
Sequence: | MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSL
RPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSS
SSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGF
AKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAG
HTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQ
TYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
EIS
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BDBM50304583 |
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n/a |
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Name | BDBM50304583 |
Synonyms: | 1alpha,25-Dihydroxy-2-methylene-18,19,21-trinorvitamin D3 | CHEMBL594078 |
Type | Small organic molecule |
Emp. Form. | C25H40O3 |
Mol. Mass. | 388.5833 |
SMILES | [#6]C([#6])([#8])[#6]-[#6]-[#6]-[#6]-[#6@H]-1-[#6]-[#6]-[#6@@H]2-[#6@@H]-1-[#6]-[#6]-[#6]\[#6]-2=[#6]/[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| |
Structure |
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