| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E synthase |
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| Ligand | BDBM31125 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_604678 (CHEMBL1068501) |
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| IC50 | 500±n/a nM |
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| Citation |  Koeberle, A; Haberl, EM; Rossi, A; Pergola, C; Dehm, F; Northoff, H; Troschuetz, R; Sautebin, L; Werz, O Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1. Bioorg Med Chem17:7924-32 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E synthase |
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| Name: | Prostaglandin E synthase |
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| Synonyms: | MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1) |
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| Type: | Protein |
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| Mol. Mass.: | 17112.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 152 |
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| Sequence: | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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| BDBM31125 |
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| n/a |
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| Name | BDBM31125 |
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| Synonyms: | 5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11d |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18FNO3 |
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| Mol. Mass. | 363.3816 |
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| SMILES | CCOC(=O)c1c(Cc2cccc(F)c2)[nH]c2c1cc(O)c1ccccc21 |
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| Structure | 
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