| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor beta |
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| Ligand | BDBM50304777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_605571 (CHEMBL1068514) |
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| Ki | 0.5±n/a nM |
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| Citation |  Li, JJ; Mitchell, LH; Dow, RL Thyroid receptor agonists for the treatment of androgenetic alopecia. Bioorg Med Chem Lett20:306-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyroid hormone receptor beta |
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| Name: | Thyroid hormone receptor beta |
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| Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
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| Type: | Receptor |
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| Mol. Mass.: | 52793.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
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| Residue: | 461 |
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| Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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| BDBM50304777 |
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| n/a |
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| Name | BDBM50304777 |
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| Synonyms: | 2-(4-(7-hydroxy-2,3-dihydro-1H-inden-4-yloxy)-3,5-dimethylphenylamino)-2-oxoacetic acid | CHEMBL608990 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19NO5 |
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| Mol. Mass. | 341.3579 |
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| SMILES | Cc1cc(NC(=O)C(O)=O)cc(C)c1Oc1ccc(O)c2CCCc12 |
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| Structure | 
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