Reaction Details |
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Target | Histone deacetylase 11 |
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Ligand | BDBM50304782 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_605920 (CHEMBL1068537) |
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IC50 | 2.1±n/a nM |
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Citation | Angibaud, P; Van Emelen, K; Decrane, L; van Brandt, S; Ten Holte, P; Pilatte, I; Roux, B; Poncelet, V; Speybrouck, D; Queguiner, L; Gaurrand, S; Mariën, A; Floren, W; Janssen, L; Verdonck, M; van Dun, J; van Gompel, J; Gilissen, R; Mackie, C; Du Jardin, M; Peeters, J; Noppe, M; Van Hijfte, L; Freyne, E; Page, M; Janicot, M; Arts, J Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. Bioorg Med Chem Lett20:294-8 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 11 |
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Name: | Histone deacetylase 11 |
Synonyms: | HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 39187.66 |
Organism: | Homo sapiens (Human) |
Description: | Q96DB2 |
Residue: | 347 |
Sequence: | MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
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BDBM50304782 |
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n/a |
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Name | BDBM50304782 |
Synonyms: | CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulfonyl)piperazin-1-yl)pyrimidine-5-carboxamide |
Type | Small organic molecule |
Emp. Form. | C19H19N5O4S |
Mol. Mass. | 413.45 |
SMILES | ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 |
Structure |
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