Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHistone deacetylase 11
LigandBDBM50304782
Substrate/Competitorn/a
Meas. Tech.ChEMBL_605920 (CHEMBL1068537)
IC50 2.1±n/a nM
Citation Angibaud, PVan Emelen, KDecrane, Lvan Brandt, STen Holte, PPilatte, IRoux, BPoncelet, VSpeybrouck, DQueguiner, LGaurrand, SMariën, AFloren, WJanssen, LVerdonck, Mvan Dun, Jvan Gompel, JGilissen, RMackie, CDu Jardin, MPeeters, JNoppe, MVan Hijfte, LFreyne, EPage, MJanicot, MArts, J Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. Bioorg Med Chem Lett20:294-8 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 11
Name:Histone deacetylase 11
Synonyms:HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:Chromatin regulator; hydrolase; repressor
Mol. Mass.:39187.66
Organism:Homo sapiens (Human)
Description:Q96DB2
Residue:347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50304782
n/a
NameBDBM50304782
Synonyms:CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulfonyl)piperazin-1-yl)pyrimidine-5-carboxamide
TypeSmall organic molecule
Emp. Form.C19H19N5O4S
Mol. Mass.413.45
SMILESONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: