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TargetTGF-beta receptor type I
LigandBDBM50304841
Substrate/Competitorn/a
Meas. Tech.ChEMBL_606316
Ki 77000±n/a nM
Citation Guckian KCarter MBLin EYChoi MSun LBoriack-Sjodin PAChuaqui CLane BCheung KLing LLee WC Pyrazolone based TGFbetaR1 kinase inhibitors. Bioorg Med Chem Lett 20:326-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
TGF-beta receptor type I
Name:TGF-beta receptor type I
Synonyms:2.7.11.30 | ALK-5 | ALK5 | ALK5 | ALK5/TGFBR1 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | Activin receptor-like kinase 5 (ALK-5) | Activin receptor-like kinase 5 (ALK5/TGFbeta) | P36897 | SKR4 | TGF-beta receptor type-1 | TGF-beta receptor type-1 (TGFR1) | TGFBR1 | Transforming Growth Factor
Type:n/a
Mol. Mass.:55968.24
Organism:Homo sapiens (Human)
Description:n/a
Residue:503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
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  Blast E-value cutoff:
BDBM50304841
n/a
NameBDBM50304841
Synonyms:4-(2-hydroxyphenyl)-1,2-dimethyl-5-(quinoxalin-6-yl)-1H-pyrazol-3(2H)-one | CHEMBL605302
TypeSmall organic molecule
Emp. Form.C19H16N4O2
Mol. Mass.332.3559
SMILESCn1c(c(-c2ccccc2O)c(=O)n1C)-c1ccc2nccnc2c1 |(.31,-34.54,;-.32,-33.14,;-1.83,-32.82,;-1.99,-31.29,;-3.33,-30.52,;-4.67,-31.29,;-6,-30.52,;-6,-28.97,;-4.67,-28.2,;-3.34,-28.97,;-2,-28.19,;-.59,-30.66,;-.27,-29.15,;.45,-31.8,;1.98,-31.64,;-3.15,-33.61,;-4.5,-32.86,;-5.82,-33.65,;-5.78,-35.19,;-7.1,-35.98,;-7.07,-37.53,;-5.72,-38.27,;-4.4,-37.48,;-4.43,-35.94,;-3.12,-35.15,)|
Structure
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