Reaction Details | |||
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Target | TGF-beta receptor type-1 | ||
Ligand | BDBM50304847 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_606317 (CHEMBL1070009) | ||
IC50 | >10000±n/a nM | ||
Citation | Guckian, K; Carter, MB; Lin, EY; Choi, M; Sun, L; Boriack-Sjodin, PA; Chuaqui, C; Lane, B; Cheung, K; Ling, L; Lee, WC Pyrazolone based TGFbetaR1 kinase inhibitors. Bioorg Med Chem Lett20:326-9 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
TGF-beta receptor type-1 | |||
Name: | TGF-beta receptor type-1 | ||
Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
Type: | enzyme | ||
Mol. Mass.: | 55968.24 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P36897 | ||
Residue: | 503 | ||
Sequence: |
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BDBM50304847 | |||
n/a | |||
Name | BDBM50304847 | ||
Synonyms: | 2-(1,2-dimethyl-3-oxo-5-(quinoxalin-6-yl)-2,3-dihydro-1H-pyrazol-4-yl)benzonitrile | CHEMBL603853 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H15N5O | ||
Mol. Mass. | 341.366 | ||
SMILES | Cn1c(c(-c2ccccc2C#N)c(=O)n1C)-c1ccc2nccnc2c1 |(.9,-4.47,;.27,-3.07,;-1.24,-2.75,;-1.4,-1.22,;-2.74,-.45,;-4.08,-1.22,;-5.41,-.45,;-5.41,1.1,;-4.08,1.87,;-2.74,1.1,;-1.41,1.88,;-.08,2.65,;0,-.59,;.32,.92,;1.04,-1.73,;2.57,-1.57,;-2.56,-3.54,;-3.9,-2.79,;-5.22,-3.58,;-5.19,-5.12,;-6.51,-5.92,;-6.48,-7.46,;-5.13,-8.2,;-3.81,-7.41,;-3.84,-5.87,;-2.53,-5.08,)| | ||
Structure |