| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
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| Ligand | BDBM50305106 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_603082 (CHEMBL1048565) |
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| Ki | 6.00±n/a nM |
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| Citation |  Shen, Z; Siva Ramamoorthy, P; Hatzenbuhler, NT; Evrard, DA; Childers, W; Harrison, BL; Chlenov, M; Hornby, G; Smith, DL; Sullivan, KM; Schechter, LE; Andree, TH Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT(1A) receptor and the serotonin transporter. Bioorg Med Chem Lett20:222-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent serotonin transporter |
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| Name: | Sodium-dependent serotonin transporter |
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| Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 70322.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31645 |
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| Residue: | 630 |
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| Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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| BDBM50305106 |
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| n/a |
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| Name | BDBM50305106 |
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| Synonyms: | (+)-8-((cyclopropylmethyl)(3-(5-fluoro-1H-indol-3-yl)propyl)amino)-2,3,8,9-tetrahydropyrano[3,2-e]isoindol-1(7H)-one | (-)-8-((cyclopropylmethyl)(3-(5-fluoro-1H-indol-3-yl)propyl)amino)-2,3,8,9-tetrahydropyrano[3,2-e]isoindol-1(7H)-one | CHEMBL607419 | Rac-8-((cyclopropylmethyl)(3-(5-fluoro-1H-indol-3-yl)propyl)amino)-2,3,8,9-tetrahydropyrano[3,2-e]isoindol-1(7H)-one |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28FN3O2 |
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| Mol. Mass. | 433.5178 |
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| SMILES | Fc1ccc2[nH]cc(CCCN(CC3CC3)C3COc4ccc5CNC(=O)c5c4C3)c2c1 |
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| Structure | 
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