| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin E |
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| Ligand | BDBM50305537 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_604246 (CHEMBL1050391) |
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| IC50 | 4±n/a nM |
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| Citation |  Lerchner, A; Machauer, R; Betschart, C; Veenstra, S; Rueeger, H; McCarthy, C; Tintelnot-Blomley, M; Jaton, AL; Rabe, S; Desrayaud, S; Enz, A; Staufenbiel, M; Paganetti, P; Rondeau, JM; Neumann, U Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application. Bioorg Med Chem Lett20:603-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin E |
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| Name: | Cathepsin E |
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| Synonyms: | 3.4.23.34 | CATE_HUMAN | CTSE | Cathepsin E form I | Cathepsin E form II |
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| Type: | Enzyme |
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| Mol. Mass.: | 43298.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14091 |
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| Residue: | 396 |
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| Sequence: | MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC
SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF
QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE
FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH
FSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNA
IGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDI
HPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP
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| BDBM50305537 |
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| n/a |
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| Name | BDBM50305537 |
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| Synonyms: | (S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-cyclopropylamino]-ethyl}-19-methyl-11,16-dioxa-3,18-diaza-tricyclo[15.3.1.1*6,10*]docosa-1(21),6(22),7,9,17,19-hexaen-2-one | CHEMBL600326 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H41N3O4 |
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| Mol. Mass. | 543.6963 |
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| SMILES | CC(C)c1cccc(c1)C1(CC1)NC[C@@H](O)[C@@H]1Cc2cccc(OCCCCOc3cc(cc(C)n3)C(=O)N1)c2 |r| |
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| Structure | 
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