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TargetMitogen-activated protein kinase 14
LigandBDBM50305694
Substrate/Competitorn/a
Meas. Tech.ChEMBL_604746 (CHEMBL1071905)
IC50 16.3±n/a nM
Citation Jerome, KDRucker, PVXing, LShieh, HSBaldus, JESelness, SRLetavic, MABraganza, JFMcClure, KF Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition. Bioorg Med Chem Lett20:469-73 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50305694
n/a
NameBDBM50305694
Synonyms:6-(2,4-difluorophenylthio)-3-(2-methylpent-4-en-2-yl)-[1,2,4]triazolo[4,3-a]pyridine hydrochloride | CHEMBL611945
TypeSmall organic molecule
Emp. Form.C18H17F2N3S
Mol. Mass.345.409
SMILESCC(C)(CC=C)c1nnc2ccc(Sc3ccc(F)cc3F)cn12
Structure
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