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TargetMitogen-activated protein kinase 14
LigandBDBM50305729
Substrate/Competitorn/a
Meas. Tech.ChEMBL_604746 (CHEMBL1071905)
IC50 26.1±n/a nM
Citation Jerome, KD; Rucker, PV; Xing, L; Shieh, HS; Baldus, JE; Selness, SR; Letavic, MA; Braganza, JF; McClure, KF Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition. Bioorg Med Chem Lett20:469-73 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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  Blast E-value cutoff:
BDBM50305729
n/a
NameBDBM50305729
Synonyms:6-(2,4-difluorobenzyl)-3-isopropyl-1,8a-dihydro-[1,2,4]triazolo[4,3-a]pyridine | CHEMBL607557
TypeSmall organic molecule
Emp. Form.C16H17F2N3
Mol. Mass.289.3231
SMILESCC(C)c1nnc2CCC(Cc3ccc(F)cc3F)=Cn12 |c:19|
Structure
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