Reaction Details |
| Report a problem with these data |
Target | Acyl-CoA desaturase 1 |
---|
Ligand | BDBM50305768 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_604760 (CHEMBL1072554) |
---|
IC50 | 2.3±n/a nM |
---|
Citation | Léger, S; Black, WC; Deschenes, D; Dolman, S; Falgueyret, JP; Gagnon, M; Guiral, S; Huang, Z; Guay, J; Leblanc, Y; Li, CS; Massé, F; Oballa, R; Zhang, L Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett20:499-502 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Acyl-CoA desaturase 1 |
---|
Name: | Acyl-CoA desaturase 1 |
Synonyms: | ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1) |
Type: | Enzyme |
Mol. Mass.: | 41485.97 |
Organism: | Rattus norvegicus (Rat) |
Description: | P07308 |
Residue: | 358 |
Sequence: | MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
|
|
|
BDBM50305768 |
---|
n/a |
---|
Name | BDBM50305768 |
Synonyms: | 2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole | CHEMBL594902 | MF-438 |
Type | Small organic molecule |
Emp. Form. | C19H18F3N5OS |
Mol. Mass. | 421.439 |
SMILES | Cc1nnc(s1)-c1ccc(nn1)N1CCC(CC1)Oc1ccccc1C(F)(F)F |
Structure |
|