| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-beta serine/threonine-protein kinase |
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| Ligand | BDBM50305878 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_605290 (CHEMBL1069942) |
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| IC50 | 12±n/a nM |
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| Citation |  Lin, H; Yamashita, DS; Zeng, J; Xie, R; Verma, S; Luengo, JI; Rhodes, N; Zhang, S; Robell, KA; Choudhry, AE; Lai, Z; Kumar, R; Minthorn, EA; Brown, KK; Heerding, DA 2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. Bioorg Med Chem Lett20:679-83 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-beta serine/threonine-protein kinase |
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| Name: | RAC-beta serine/threonine-protein kinase |
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| Synonyms: | AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta |
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| Type: | Enzyme |
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| Mol. Mass.: | 55766.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 481 |
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| Sequence: | MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
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| BDBM50305878 |
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| n/a |
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| Name | BDBM50305878 |
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| Synonyms: | (2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxy}-3-(1H-indol-3-yl)propan-2-amine | (S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-(1H-indol-3-yl)propan-2-amine | CHEMBL593490 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H25N5O2 |
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| Mol. Mass. | 463.5304 |
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| SMILES | Cc1n[nH]c2ccc(cc12)-c1cc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cnc1-c1ccoc1 |r| |
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| Structure | 
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