Reaction Details |
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Target | RAC-gamma serine/threonine-protein kinase |
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Ligand | BDBM50305881 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_605291 (CHEMBL1069943) |
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IC50 | 10±n/a nM |
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Citation | Lin, H; Yamashita, DS; Zeng, J; Xie, R; Verma, S; Luengo, JI; Rhodes, N; Zhang, S; Robell, KA; Choudhry, AE; Lai, Z; Kumar, R; Minthorn, EA; Brown, KK; Heerding, DA 2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. Bioorg Med Chem Lett20:679-83 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RAC-gamma serine/threonine-protein kinase |
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Name: | RAC-gamma serine/threonine-protein kinase |
Synonyms: | AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3 |
Type: | Enzyme |
Mol. Mass.: | 55769.36 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 479 |
Sequence: | MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
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BDBM50305881 |
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n/a |
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Name | BDBM50305881 |
Synonyms: | (S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-b]pyrazin-5-yl)pyridin-3-yloxy)-3-(1H-indol-3-yl)propan-2-amine | CHEMBL596290 |
Type | Small organic molecule |
Emp. Form. | C26H23N7O2 |
Mol. Mass. | 465.5065 |
SMILES | Cc1n[nH]c2ncc(nc12)-c1cc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cnc1-c1ccoc1 |r| |
Structure |
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