Reaction Details |
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Target | Stearoyl-CoA desaturase |
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Ligand | BDBM50306126 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_606058 (CHEMBL1071957) |
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IC50 | 0.45±n/a nM |
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Citation | Uto, Y; Kiyotsuka, Y; Ueno, Y; Miyazawa, Y; Kurata, H; Ogata, T; Deguchi, T; Yamada, M; Watanabe, N; Konishi, M; Kurikawa, N; Takagi, T; Wakimoto, S; Kono, K; Ohsumi, J Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine]. Bioorg Med Chem Lett20:746-54 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Stearoyl-CoA desaturase |
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Name: | Stearoyl-CoA desaturase |
Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
Type: | Enzyme |
Mol. Mass.: | 41537.27 |
Organism: | Homo sapiens (Human) |
Description: | O00767 |
Residue: | 359 |
Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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BDBM50306126 |
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n/a |
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Name | BDBM50306126 |
Synonyms: | CHEMBL605412 | N-(2-hydroxy-2-(pyridin-3-yl)ethyl)-6-(5-(trifluoromethyl)spiro[chroman-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide |
Type | Small organic molecule |
Emp. Form. | C26H26F3N5O3 |
Mol. Mass. | 513.5115 |
SMILES | OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CCc1c(O2)cccc1C(F)(F)F)c1cccnc1 |
Structure |
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