| Reaction Details |
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 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
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| Ligand | BDBM50306116 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_606060 (CHEMBL1071959) |
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| IC50 | 0.068±n/a nM |
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| Citation |  Uto, Y; Kiyotsuka, Y; Ueno, Y; Miyazawa, Y; Kurata, H; Ogata, T; Deguchi, T; Yamada, M; Watanabe, N; Konishi, M; Kurikawa, N; Takagi, T; Wakimoto, S; Kono, K; Ohsumi, J Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine]. Bioorg Med Chem Lett20:746-54 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stearoyl-CoA desaturase |
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| Name: | Stearoyl-CoA desaturase |
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| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41537.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00767 |
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| Residue: | 359 |
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| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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| BDBM50306116 |
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| n/a |
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| Name | BDBM50306116 |
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| Synonyms: | CHEMBL594289 | N-(2-hydroxy-2-phenylethyl)-6-(spiro[chroman-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28N4O3 |
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| Mol. Mass. | 444.5255 |
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| SMILES | OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CCc1ccccc1O2)c1ccccc1 |
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| Structure | 
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