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TargetStearoyl-CoA desaturase
LigandBDBM50306131
Substrate/Competitorn/a
Meas. Tech.ChEMBL_606060 (CHEMBL1071959)
IC50 0.8±n/a nM
Citation Uto, YKiyotsuka, YUeno, YMiyazawa, YKurata, HOgata, TDeguchi, TYamada, MWatanabe, NKonishi, MKurikawa, NTakagi, TWakimoto, SKono, KOhsumi, J Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine]. Bioorg Med Chem Lett20:746-54 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Stearoyl-CoA desaturase
Name:Stearoyl-CoA desaturase
Synonyms:Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1
Type:Enzyme
Mol. Mass.:41537.27
Organism:Homo sapiens (Human)
Description:O00767
Residue:359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50306131
n/a
NameBDBM50306131
Synonyms:1'-(6-(5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl)pyridazin-3-yl)-5-(trifluoromethyl)spiro[chroman-2,4'-piperidine] | CHEMBL593108
TypeSmall organic molecule
Emp. Form.C26H23F3N6O2
Mol. Mass.508.495
SMILESFC(F)(F)c1cccc2OC3(CCN(CC3)c3ccc(nn3)-c3nnc(Cc4cccnc4)o3)CCc12
Structure
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