Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCoagulation factor X
LigandBDBM50306140
Substrate/Competitorn/a
Meas. Tech.ChEMBL_606078 (CHEMBL1071977)
Ki 1±n/a nM
Citation Kleanthous, SBorthwick, ADBrown, DBurns-Kurtis, CLCampbell, MChaudry, LChan, CClarte, MOConvery, MAHarling, JDHortense, EIrving, WRIrvine, SPateman, AJPatikis, ANPinto, ILPollard, DRRoethka, TJSenger, SShah, GPStelman, GJToomey, JRWatson, NSWest, RIWhittaker, CZhou, PYoung, RJ Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs. Bioorg Med Chem Lett20:618-22 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50306140
n/a
NameBDBM50306140
Synonyms:6-chloro-N-((3S)-1-(2-fluoro-4-(1-(isopropylamino)ethyl)phenyl)-2-oxopyrrolidin-3-yl)naphthalene-2-sulfonamide | CHEMBL593586
TypeSmall organic molecule
Emp. Form.C25H27ClFN3O3S
Mol. Mass.504.017
SMILESCC(C)NC(C)c1ccc(N2CC[C@H](NS(=O)(=O)c3ccc4cc(Cl)ccc4c3)C2=O)c(F)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: